Hydrochloride methanol → HCID 67468018, compound

HRID 1850294Notes

Reaction equation

C(OC([N:8]1[CH2:11][CH:10]([C:12]2[C:21]([N:22]3[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]3)=[N:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=2)[CH2:9]1)=O)(C)(C)C.[ClH:28].CO>>[ClH:28].[NH:8]1[CH2:9][CH:10]([C:12]2[C:21]([N:22]3[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]3)=[N:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=2)[CH2:11]1

Participants

Reactant 2

HCID 21893726Hydrochloride methanol

HCID 58546763HCID 58546763, compound

Product 1

HCID 67468018HCID 67468018, compoundYield 100%

Procedure

A mixture of 3-(3-piperidin-1-yl-quinoxalin-2-yl)-azetidine-1-carboxylic acid tert-butyl ester (92) (139 mg, 0.38 mmol) in 4 M HCl/MeOH solution (10 mL) was stirred at RT for 30 min. Then the solvent was evaporated at 40° C. to give 2-azetidin-3-yl-3-piperidin-1-yl-quinoxaline hydrochloride (93) (115 mg, 0.38 mmol, 100% yield) as a yellow solid. ESI-MS (M+1): 269 calc. for C16H20N4 269

Workup

customThen the solvent was evaporated at 40° C.

Sources & evidence

ORD record: ord-1760c2c39e6d4798a3063e11faeb4068
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08957073B2

Reaction notes

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