Hydrochloride methanol → HCID 67997380, compound

HRID 1850299Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:19]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:26].CO>>[ClH:26].[C:20]1([C:19]2[C:14]([CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[N:15][CH:16]=[CH:17][CH:18]=2)[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

Reactant 2

HCID 21893726Hydrochloride methanol

HCID 58546733HCID 58546733, compound

Product 1

HCID 67997380HCID 67997380, compoundYield 100%

Procedure

A mixture of 3-phenyl-3′,4′,5′,6′-tetrahydro-2′H-[2,4′]bipyridinyl-1′-carboxylic acid tert-butyl ester (102) (202 mg, 0.60 mmol) in HCl/MeOH solution (5 mL) was stirred at RT. for 30 min. Then the solvent was evaporated at 40° C. to give 3-phenyl-1′,2′,3′,4′,5′,6′-hexahydro-[2,4′]bipyridinyl hydrochloride (103) (162 mg, 0.60 mmol, 100% yield) as a yellow solid.

Workup

customThen the solvent was evaporated at 40° C.

Sources & evidence

ORD record: ord-f28f89c06a9243ac9a46f8de87f5bec2
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08957073B2

Reaction notes

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