Acetic Anhydride → HCID 58547206, compound

Participants

Reaction Steps

To a solution of 2,6-diaza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester (130) (purchased from WUXI APPTEC®) ((500 mg, 2.73 mmol) in CH2Cl2 (10 mL) were added KOH (459 mg, 8.19 mmol) and Ac2O (279 mg, 2.73 mmol). The reaction mixture was stirred at RT for 1 h, then diluted with CH2Cl2 (20 mL), washed with H2O (20 mL). The organic layer was washed with brine (20 mL), dried over Na2SO4, and filtered, evaporated to give the product (131) (510 mg, 2.13 mmol, yield: 78%). ESI-MS (M+1): 241 calc. for C12H20N2O3 240.

Provenance & Evidence