HCID 58547322, compound → HCID 86660170, compound

HRID 1850337Notes

Reaction equation

HRID 1850337 reaction equation
C(OC([N:8]1[CH2:11][CH:10]([C:12]2[C:17]([Br:18])=[CH:16][N:15]=[C:14]([Cl:19])[N:13]=2)[CH2:9]1)=O)(C)(C)C>Cl.CO>[ClH:19].[NH:8]1[CH2:11][CH:10]([C:12]2[C:17]([Br:18])=[CH:16][N:15]=[C:14]([Cl:19])[N:13]=2)[CH2:9]1

Participants

3

Reactant 1

HCID 58547322HCID 58547322, compound

Product 1

HCID 86660170HCID 86660170, compoundYield 200%

Reagents, catalysts & solvents 1

HCID 21893726Hydrochloride methanolSolvent

Procedure

The mixture of 3-(5-bromo-2-chloro-pyrimidin-4-yl)-azetidine-1-carboxylic acid tert-butyl ester (0.7 g, 2.0 mmol) in HCl/MeOH (10 mL) was stirred at RT for 1 h. Then it was concentrated to give 4-azetidin-3-yl-5-bromo-2-chloro-pyrimidine hydrochloride (0.57 g, 2.0 mmol, yield 100%) which was used in the next step without further purification. ESI-MS (M+1): 248 calc. for C7H7BrClN3 247.

Workup

  1. concentrationThen it was concentrated

Sources & evidence

ORD record
ord-2a1576dda1a04f2b909a996bfedb7dde
Source dataset
uspto-grants-2015_02
Patent number
US08957073B2

Reaction notes

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