Sodium Carbonate → HCID 58547508, compound

Participants

Reaction Steps

A solution of (1H-benzoimidazol-2-yl)-[3-(5-bromo-2-chloro-pyrimidin-4-yl)-azetidin-1-yl]-methanone (206 mg, 0.53 mmol) in dioxane (15 mL) was treated with Na2CO3 (112 mg, 1.1 mmol dissolved 1 mL of H2O), followed by additional of phenylboronic acid (78 mg 0.64 mmol) and Pd(dppf)Cl2 (37 mg, 0.05 mmol). The resulting mixture was heated at refluxing overnight under N2 atmosphere. TLC showed that most of the staring materials were consumed completely. The solution was filtered, and the filter was concentrated. And the residue was purified by silica gel chromatography to give the product (102 mg, 0.28 mmol, yield: 53%). ESI-MS (M+1): 362 calc. for C21H16ClN5O 361.

Provenance & Evidence