Sodium borohydride → (Racemic)-1-{1-[3-(1-quinolin-2-yl-azetidin-3-yl)-pyrazin-2-yl]-piperidin-4-yl}-ethanol

Participants

Reaction Steps

A solution of 1-{1-[3-(1-quinolin-2-yl-azetidin-3-yl)-pyrazin-2-yl]-piperidin-4-yl}-ethanone (96.75 mg, 0.25 mmol) in MeOH (10 mL) was added NaBH4 (37 mg, 1 mmol). The mixture was stirred at RT for 2 h. The reaction mixture was concentrated to give the product (racemic)-1-{1-[3-(1-quinolin-2-yl-azetidin-3-yl)-pyrazin-2-yl]-piperidin-4-yl}-ethanol (76 mg, 0.20 mmol, yield 78%).

Provenance & Evidence