tert-Butanol → HCID 58547265, compound

Participants

Reaction Steps

A mixture of 3-(3-(1-(quinolin-2-yl)azetidin-3-yl)pyrazin-2-yl)benzonitrile (0.072 g, 0.198 mmol), potassium hydroxide (0.111 g, 1.981 mmol, v/w) and t-BuOH (2 mL, Acros) was heated at 80° C. overnight. LCMS showed the product. The mixture was diluted with water and extracted with a mixture of CHCl3:i-PrOH (3:1) three times. The combined organic layers were dried over Na2SO4 and concentrated in vacuo. The product was obtained as a white solid (75 mg, 99%).

Provenance & Evidence