Trifluoroacetic acid → HCID 58546859, compound

Participants

Reaction Steps

A mixture of tert-butyl 4-(3-(1-(quinolin-2-yl)azetidin-3-yl)pyrazin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate (0.100 g, 0.225 mmol, SCHEME 5) CH2Cl2 (1 mL) and TFA (0.174 mL, 2.255 mmol) was stirred at RT for 1 h. LCMS showed the product and no more starting material was present. The mixture was concentrated in vacuo and neutralized with Na2CO3. The mixture was extracted with a mixture of CHCl3:i-PrOH (3:1) three times. The organic layer was dried over Na2SO4 and concentrated in vacuo. The product was obtained as a white solid (77 mg, 99%).

Provenance & Evidence