Formamide → HCID 178508717, compound

HRID 1850367Notes

Reaction equation

HRID 1850367 reaction equation
[NH2:1][C:2]1[C:6]([C:7]#[N:8])=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([O:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:11][CH:10]=2)[NH:4][N:3]=1.O.[CH:23]([NH2:25])=O>>[NH2:8][C:7]1[N:25]=[CH:23][N:1]=[C:2]2[NH:3][N:4]=[C:5]([C:9]3[CH:14]=[CH:13][C:12]([O:15][C:16]4[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=4)=[CH:11][CH:10]=3)[C:6]=12

Participants

4

Reactant 3

HCID 713FormamideHCID 962WaterHCID 223467843-amino-5-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

Product 1

HCID 178508717HCID 178508717, compound

Conditions

Temperature
180 °C

Procedure

3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole (29.5 g) is suspended in formamide (300 mL) and heated under nitrogen at 180° C. for 4 hours. The reaction mixture is cooled to 30 OC and water (300 mL) is added. The solid is collected, washed well with water, then with methanol and dried in air to give of 4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine.

Workup

  1. additionis added
  2. customThe solid is collected
  3. washwashed well with water
  4. dry with materialwith methanol and dried in air

Sources & evidence

ORD record
ord-5aea05ecb0bb447489948b5c58ae1117
Source dataset
uspto-grants-2015_02
Patent number
US08957079B2

Reaction notes

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