2-(4-Methoxyphenyl)morpholine → HCID 66760147, compound

HRID 1850400Notes

Reaction equation

HRID 1850400 reaction equation
Br[C:2]1[C:3]([CH3:15])=[C:4]([CH3:14])[C:5]2[O:9][C:8]([CH3:11])([CH3:10])[C:7](=[O:12])[C:6]=2[CH:13]=1.[CH3:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([CH:24]2[O:29][CH2:28][CH2:27][NH:26][CH2:25]2)=[CH:20][CH:19]=1>>[CH3:16][O:17][C:18]1[CH:19]=[CH:20][C:21]([CH:24]2[O:29][CH2:28][CH2:27][N:26]([C:2]3[C:3]([CH3:15])=[C:4]([CH3:14])[C:5]4[O:9][C:8]([CH3:11])([CH3:10])[C:7](=[O:12])[C:6]=4[CH:13]=3)[CH2:25]2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 37595462-(4-Methoxyphenyl)morpholineHCID 667597135-bromo-2,2,6,7-tetramethyl-1-benzofuran-3(2H)-one

Product 1

HCID 66760147HCID 66760147, compoundYield 34.1%

Procedure

By using 5-bromo-2,2,6,7-tetramethyl-1-benzofuran-3(2H)-one (488 mg, 1.72 mmol) synthesized in Reference Example 18 and 2-(4-methoxyphenyl)morpholine (500 mg, 2.59 mmol), the reaction was carried out in the same manner as Reference Example 59 to synthesize 224 mg of the title compound (yield 34%).

Sources & evidence

ORD record
ord-3b73b0ff9ce4446b9c431504fd025675
Source dataset
uspto-grants-2015_02
Patent number
US08957069B2

Reaction notes

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