1-(4-Methoxyphenyl)piperazine → HCID 59485128, compound

HRID 1850425Notes

Reaction equation

HRID 1850425 reaction equation
Br[C:2]1[C:3]([C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)=[CH:4][C:5]2[O:9][C:8]([CH3:11])([CH3:10])[CH2:7][C:6]=2[CH:12]=1.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[CH:24][CH:23]=1>>[CH3:10][C:8]1([CH3:11])[CH2:7][C:6]2[CH:12]=[C:2]([N:31]3[CH2:30][CH2:29][N:28]([C:25]4[CH:24]=[CH:23][C:22]([O:21][CH3:20])=[CH:27][CH:26]=4)[CH2:33][CH2:32]3)[C:3]([C:13]3[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=3)=[CH:4][C:5]=2[O:9]1

Participants

3

Reactant 2

HCID 2697221-(4-Methoxyphenyl)piperazineHCID 66759597HCID 66759597, compound

Product 1

HCID 59485128HCID 59485128, compoundYield 16.3%

Procedure

By using 5-bromo-2,2-dimethyl-6-(4-methylphenyl)-2,3-dihydro-1-benzofuran (250 mg, 0.788 mmol) synthesized in Reference example 9 and 1-(4-methoxyphenyl)piperazine (455 mg, 2.36 mmol), the reaction was carried out in the same manner as Example 1 to synthesize the title compound 55 mg (yield 16%). Melting point was 187 to 190° C. (ethyl acetate-hexane).

Sources & evidence

ORD record
ord-ad0209f87e5641b8b22e553a231dd478
Source dataset
uspto-grants-2015_02
Patent number
US08957069B2

Reaction notes

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