1-(4-Methoxyphenyl)piperazine → HCID 59485097, compound

HRID 1850426Notes

Reaction equation

HRID 1850426 reaction equation
Br[C:2]1[C:3]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)=[CH:4][C:5]2[O:9][C:8]([CH3:11])([CH3:10])[CH2:7][C:6]=2[CH:12]=1.[CH3:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[CH:23][CH:22]=1>>[CH3:10][C:8]1([CH3:11])[CH2:7][C:6]2[CH:12]=[C:2]([N:30]3[CH2:29][CH2:28][N:27]([C:24]4[CH:23]=[CH:22][C:21]([O:20][CH3:19])=[CH:26][CH:25]=4)[CH2:32][CH2:31]3)[C:3]([C:13]3[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=3)=[CH:4][C:5]=2[O:9]1

Participants

3

Reactant 2

HCID 2697221-(4-Methoxyphenyl)piperazineHCID 66760347HCID 66760347, compound

Product 1

HCID 59485097HCID 59485097, compoundYield 46%

Procedure

By using 3-(5-bromo-2,2-dimethyl-2,3-dihydro-1-benzofuran-6-yl)pyridine (160 mg, 0.526 mmol) synthesized in Reference example 11 and 1-(4-methoxyphenyl)piperazine (303 mg, 1.58 mmol), the reaction was carried out in the same manner as Example 1 to synthesize the title compound 100 mg (yield 46%).

Sources & evidence

ORD record
ord-364a2424504242c8896204464f3a6a0e
Source dataset
uspto-grants-2015_02
Patent number
US08957069B2

Reaction notes

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