1-(4-Methoxyphenyl)piperazine → HCID 59485014, compound

HRID 1850427Notes

Reaction equation

HRID 1850427 reaction equation
Br[C:2]1[C:3]([CH3:14])=[C:4]([CH3:13])[C:5]2[O:9][C:8]([CH3:11])([CH3:10])[CH2:7][C:6]=2[CH:12]=1.[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:19][CH:18]=1>>[CH3:15][O:16][C:17]1[CH:18]=[CH:19][C:20]([N:23]2[CH2:28][CH2:27][N:26]([C:2]3[C:3]([CH3:14])=[C:4]([CH3:13])[C:5]4[O:9][C:8]([CH3:11])([CH3:10])[CH2:7][C:6]=4[CH:12]=3)[CH2:25][CH2:24]2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 2697221-(4-Methoxyphenyl)piperazineHCID 66760117HCID 66760117, compound

Product 1

HCID 59485014HCID 59485014, compoundYield 58%

Procedure

By using 5-bromo-2,2,6,7-tetramethyl-2,3-dihydro-1-benzofuran (300 mg, 1.18 mmol) synthesized in Reference example 15 and 1-(4-methoxyphenyl)piperazine (678 mg, 3.53 mmol), the reaction was carried out in the same manner as Example 1 to obtain the title compound 250 mg (yield 58%). Melting point was 180 to 182° C. (ethyl acetate-hexane).

Sources & evidence

ORD record
ord-b301aa4f5c7b4b1cbe83678a15128912
Source dataset
uspto-grants-2015_02
Patent number
US08957069B2

Reaction notes

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