Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1850440Generated: October 30, 2026

5-Bromo-2-chlorotoluene → HCID 59485060, compound

https://huagongshe.com/reaction/1850440

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromo-2-chlorotolueneHCID 609899—
Reactant1-(2,2,4,6,7-Pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazineHCID 66759731—
ProductHCID 59485060HCID 5948506015%

Reaction Steps

By using 1-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine (274 mg, 1.00 mmol) synthesized in Reference example 61 and 4-bromo-1-chloro-2-methylbenzene (308 mg, 1.50 mmol), the reaction was carried out in the same manner as Example 23 to obtain the title compound 60 mg (yield 15%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08957069B2
Source datasetuspto-grants-2015_02
ORD IDord-973d42f3b2aa47c69332578f27953387
Source noteuspto-grants-2015_02