1-(4-Methoxyphenyl)piperazine → HCID 59484991, compound

HRID 1850454Notes

Reaction equation

HRID 1850454 reaction equation
Br[C:2]1[C:3]([CH3:15])=[C:4]([O:13][CH3:14])[C:5]2[O:9][CH:8]([CH3:10])[CH2:7][C:6]=2[C:11]=1[CH3:12].[CH3:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)=[CH:20][CH:19]=1>>[CH3:16][O:17][C:18]1[CH:19]=[CH:20][C:21]([N:24]2[CH2:29][CH2:28][N:27]([C:2]3[C:3]([CH3:15])=[C:4]([O:13][CH3:14])[C:5]4[O:9][CH:8]([CH3:10])[CH2:7][C:6]=4[C:11]=3[CH3:12])[CH2:26][CH2:25]2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 2697221-(4-Methoxyphenyl)piperazineHCID 66760475HCID 66760475, compound

Product 1

HCID 59484991HCID 59484991, compoundYield 55%

Procedure

By using 5-bromo-7-methoxy-2,4,6-trimethyl-2,3-dihydro-1-benzofuran (542 mg, 2.0 mmol) synthesized in Reference example 83 and 1-(4-methoxyphenyl)piperazine (768 mg, 4.0 mmol), the reaction was carried out in the same manner as Example 21 to synthesize the title compound 420 mg (yield 55%).

Sources & evidence

ORD record
ord-b88fcb7718a9437799993ba2544907cd
Source dataset
uspto-grants-2015_02
Patent number
US08957069B2

Reaction notes

Loading…