1-(p-Tolyl)piperazine → HCID 59485099, compound

HRID 1850455Notes

Reaction equation

HRID 1850455 reaction equation
Br[C:2]1[C:3]([CH3:15])=[C:4]([O:13][CH3:14])[C:5]2[O:9][CH:8]([CH3:10])[CH2:7][C:6]=2[C:11]=1[CH3:12].[CH3:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:19][CH:18]=1>>[CH3:14][O:13][C:4]1[C:5]2[O:9][CH:8]([CH3:10])[CH2:7][C:6]=2[C:11]([CH3:12])=[C:2]([N:26]2[CH2:27][CH2:28][N:23]([C:20]3[CH:21]=[CH:22][C:17]([CH3:16])=[CH:18][CH:19]=3)[CH2:24][CH2:25]2)[C:3]=1[CH3:15]

Participants

3

Reactant 2

HCID 831131-(p-Tolyl)piperazineHCID 66760475HCID 66760475, compound

Product 1

HCID 59485099HCID 59485099, compoundYield 42%

Procedure

By using 5-bromo-7-methoxy-2,4,6-trimethyl-2,3-dihydro-1-benzofuran (542 mg, 2.0 mmol) synthesized in Reference example 83 and 1-(4-methylphenyl)piperazine (704 mg, 4.0 mmol), the reaction was carried out in the same manner as Example 21 to synthesize the title compound 306 mg (yield 42%).

Sources & evidence

ORD record
ord-03e9f21e7faf457c96b8f4b63050b39b
Source dataset
uspto-grants-2015_02
Patent number
US08957069B2

Reaction notes

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