N-(3-methoxyphenyl)piperazine → HCID 59485022, compound

HRID 1850458Notes

Reaction equation

HRID 1850458 reaction equation
Br[C:2]1[C:3]([CH3:15])=[C:4]([O:13][CH3:14])[C:5]2[O:9][CH:8]([CH3:10])[CH2:7][C:6]=2[C:11]=1[CH3:12].[CH3:16][O:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1>>[CH3:16][O:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][N:27]([C:2]3[C:3]([CH3:15])=[C:4]([O:13][CH3:14])[C:5]4[O:9][CH:8]([CH3:10])[CH2:7][C:6]=4[C:11]=3[CH3:12])[CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 81430N-(3-methoxyphenyl)piperazineHCID 66760475HCID 66760475, compound

Product 1

HCID 59485022HCID 59485022, compoundYield 44.4%

Procedure

By using 5-bromo-7-methoxy-2,4,6-trimethyl-2,3-dihydro-1-benzofuran (542 mg, 2.0 mmol) synthesized in Reference example 83 and 1-(3-methoxyphenyl)piperazine (768 mg, 4.0 mmol), the reaction was carried out in the same manner as Example 21 to obtain the title compound 340 mg (yield 44%) as an oily substance.

Sources & evidence

ORD record
ord-d9b99b9576aa48c0a3b59edac61b1ef0
Source dataset
uspto-grants-2015_02
Patent number
US08957069B2

Reaction notes

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