1-(4-Methoxyphenyl)piperazine → HCID 59485078, compound

HRID 1850461Notes

Reaction equation

HRID 1850461 reaction equation
Br[C:2]1[C:3]([CH3:17])=[C:4]([O:13][CH:14]([CH3:16])[CH3:15])[C:5]2[O:9][CH:8]([CH3:10])[CH2:7][C:6]=2[C:11]=1[CH3:12].[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[CH:22][CH:21]=1>>[CH3:18][O:19][C:20]1[CH:21]=[CH:22][C:23]([N:26]2[CH2:31][CH2:30][N:29]([C:2]3[C:3]([CH3:17])=[C:4]([O:13][CH:14]([CH3:16])[CH3:15])[C:5]4[O:9][CH:8]([CH3:10])[CH2:7][C:6]=4[C:11]=3[CH3:12])[CH2:28][CH2:27]2)=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 2697221-(4-Methoxyphenyl)piperazineHCID 66760438HCID 66760438, compound

Product 1

HCID 59485078HCID 59485078, compoundYield 34%

Procedure

By using 5-bromo-2,4,6-trimethyl-7-(1-methylethoxy)-2,3-dihydro-1-benzofuran (598 mg, 2.0 mmol) synthesized in Reference example 85 and 1-(4-methoxyphenyl)piperazine (768 mg, 4.0 mmol), the reaction was carried out in the same manner as Example 21 to synthesize the title compound 276 mg (yield 34%). Melting point was 110 to 112° C. (ethanol-water).

Sources & evidence

ORD record
ord-e4dc35c0f1f34dcea9c007f520df0ee5
Source dataset
uspto-grants-2015_02
Patent number
US08957069B2

Reaction notes

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