4-Bromo-1-methoxy-2-methylbenzene → HCID 59485111, compound

HRID 1850463Notes

Reaction equation

HRID 1850463 reaction equation
[CH3:1][O:2][C:3]1[C:11]2[O:10][CH:9]([CH3:12])[CH2:8][C:7]=2[C:6]([CH3:13])=[C:5]([N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[C:4]=1[CH3:20].Br[C:22]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[C:24]([CH3:30])[CH:23]=1>>[CH3:29][O:28][C:25]1[CH:26]=[CH:27][C:22]([N:17]2[CH2:18][CH2:19][N:14]([C:5]3[C:4]([CH3:20])=[C:3]([O:2][CH3:1])[C:11]4[O:10][CH:9]([CH3:12])[CH2:8][C:7]=4[C:6]=3[CH3:13])[CH2:15][CH2:16]2)=[CH:23][C:24]=1[CH3:30]

Participants

3

Reactant 2

HCID 6083154-Bromo-1-methoxy-2-methylbenzeneHCID 66759462HCID 66759462, compound

Product 1

HCID 59485111HCID 59485111, compoundYield 41%

Procedure

By using 1-(7-methoxy-2,4,6-trimethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine (552 mg, 2.0 mmol) synthesized in Reference example 88 and 4-bromo-1-methoxy-2-methylbenzene (804 mg, 4.0 mmol), the reaction was carried out in the same manner as Example 23 to synthesize the title compound 323 mg (yield 41%). Melting point was 94 to 96° C. (ethanol-water).

Sources & evidence

ORD record
ord-3f221b4df1374c42bf015bc0be09b23d
Source dataset
uspto-grants-2015_02
Patent number
US08957069B2

Reaction notes

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