1-Bromo-4-(trifluoromethoxy)benzene → HCID 59485069, compound

HRID 1850473Notes

Reaction equation

HRID 1850473 reaction equation
[CH3:1][O:2][C:3]1[C:11]2[O:10][C:9]([CH3:13])([CH3:12])[CH2:8][C:7]=2[C:6]([CH3:14])=[C:5]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[C:4]=1[CH3:21].Br[C:23]1[CH:28]=[CH:27][C:26]([O:29][C:30]([F:33])([F:32])[F:31])=[CH:25][CH:24]=1>>[CH3:1][O:2][C:3]1[C:11]2[O:10][C:9]([CH3:13])([CH3:12])[CH2:8][C:7]=2[C:6]([CH3:14])=[C:5]([N:15]2[CH2:20][CH2:19][N:18]([C:23]3[CH:24]=[CH:25][C:26]([O:29][C:30]([F:31])([F:32])[F:33])=[CH:27][CH:28]=3)[CH2:17][CH2:16]2)[C:4]=1[CH3:21]

Participants

3

Reactant 2

HCID 5210081-Bromo-4-(trifluoromethoxy)benzeneHCID 66760421HCID 66760421, compound

Product 1

HCID 59485069HCID 59485069, compoundYield 23.7%

Procedure

By using 1-(7-methoxy-2,2,4,6-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine (436 mg, 1.50 mmol) synthesized in Reference example 96 and 1-bromo-4-(trifluoromethoxy)benzene (542 mg, 2.25 mmol), the reaction was carried out in the same manner as Reference example 59 to synthesize the title compound 160 mg (yield 16%). Melting point was 162 to 164° C. (hexane).

Sources & evidence

ORD record
ord-b088d05de0e84fb48bb663d02cd0817a
Source dataset
uspto-grants-2015_02
Patent number
US08957069B2

Reaction notes

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