2-(4-Methoxyphenyl)morpholine → HCID 59485071, compound

HRID 1850481Notes

Reaction equation

HRID 1850481 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH3:14])[C:5]2[O:9][C:8]([CH3:11])([CH3:10])[CH2:7][C:6]=2[C:12]=1[CH3:13].[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([CH:23]2[O:28][CH2:27][CH2:26][NH:25][CH2:24]2)=[CH:19][CH:18]=1>>[CH3:15][O:16][C:17]1[CH:18]=[CH:19][C:20]([CH:23]2[O:28][CH2:27][CH2:26][N:25]([C:2]3[CH:3]=[C:4]([CH3:14])[C:5]4[O:9][C:8]([CH3:11])([CH3:10])[CH2:7][C:6]=4[C:12]=3[CH3:13])[CH2:24]2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 37595462-(4-Methoxyphenyl)morpholineHCID 667604235-Bromo-2,2,4,7-tetramethyl-2,3-dihydro-1-benzofuran

Product 1

HCID 59485071HCID 59485071, compoundYield 56.1%

Procedure

By using 5-bromo-2,2,4,7-tetramethyl-2,3-dihydro-1-benzofuran (510 mg, 2.00 mmol) synthesized in Reference example 103 and 2-(4-methoxyphenyl)morpholine (773 mg, 4.00 mmol), the reaction was carried out in the same manner as Example 1 to synthesize the title compound 412 mg (yield 56%).

Sources & evidence

ORD record
ord-7ba21a7bebf34a0289f7714f93635cba
Source dataset
uspto-grants-2015_02
Patent number
US08957069B2

Reaction notes

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