HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2,4-dimethoxyphenyl)piperazine → 1-(2,4-Dimethoxyphenyl)-4-(2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2,4-dimethoxyphenyl)piperazine | HCID 2736204 | — |
| Reactant | 5-Bromo-2,4,6,7-tetramethyl-2,3-dihydrobenzofuran | HCID 66760287 | — |
| Product | 1-(2,4-Dimethoxyphenyl)-4-(2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine | HCID 59485042 | 54% |
Reaction Steps
By using 5-bromo-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran (480 mg, 1.88 mmol) synthesized in Reference example 53 and 1-(2,4-dimethoxyphenyl)piperazine (627 mg, 2.82 mmol), the reaction was carried out in the same manner as Example 1 to obtain the title compound 400 mg (yield 54%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957069B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-75a7112ca4884855a805adb14baa3f98 |
| Source note | uspto-grants-2015_02 |