Pyrazol-3-ylamine → HCID 178426243, compound

HRID 1850504Notes

Reaction equation

HRID 1850504 reaction equation
Cl[CH2:2][CH2:3][N:4]([CH2:19][CH2:20]Cl)[C:5]1[C:6]([CH3:18])=[C:7]([CH3:17])[C:8]2[O:12][C:11]([CH3:14])([CH3:13])[CH2:10][C:9]=2[C:15]=1[CH3:16].[NH:22]1[C:26]([NH2:27])=[CH:25][CH:24]=[N:23]1>>[CH3:13][C:11]1([CH3:14])[CH2:10][C:9]2[C:15]([CH3:16])=[C:5]([N:4]3[CH2:19][CH2:20][N:27]([C:26]4[CH:25]=[CH:24][NH:23][N:22]=4)[CH2:2][CH2:3]3)[C:6]([CH3:18])=[C:7]([CH3:17])[C:8]=2[O:12]1

Participants

3

Reactant 2

HCID 74561Pyrazol-3-ylamineHCID 66760837N,N-bis(2-chloroethyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-amine

Product 1

HCID 178426243HCID 178426243, compoundYield 13.5%

Procedure

By using N,N-bis(2-chloroethyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-amine (165 mg, 0.50 mmol) synthesized in Reference Example 146 and 1H-pyrazole-5-amine (59 mg, 0.60 mmol), the reaction was carried out in the same manner as Example 117 to obtain 23 mg of the title compound as a colorless solid (yield 12%).

Sources & evidence

ORD record
ord-52d4117c65ed44c18e431be805116df4
Source dataset
uspto-grants-2015_02
Patent number
US08957069B2

Reaction notes

Loading…