1-(4-Methoxyphenyl)piperazine → HCID 59485055, compound

HRID 1850514Notes

Reaction equation

HRID 1850514 reaction equation
[CH2:1]([O:8][CH2:9][C:10]1([CH3:23])[CH2:14][C:13]2[C:15]([CH3:22])=[C:16](Br)[C:17]([CH3:20])=[C:18]([CH3:19])[C:12]=2[O:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([N:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)=[CH:28][CH:27]=1>>[CH2:1]([O:8][CH2:9][C:10]1([CH3:23])[CH2:14][C:13]2[C:15]([CH3:22])=[C:16]([N:35]3[CH2:34][CH2:33][N:32]([C:29]4[CH:28]=[CH:27][C:26]([O:25][CH3:24])=[CH:31][CH:30]=4)[CH2:37][CH2:36]3)[C:17]([CH3:20])=[C:18]([CH3:19])[C:12]=2[O:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 2697221-(4-Methoxyphenyl)piperazineHCID 66760708HCID 66760708, compound

Product 1

HCID 59485055HCID 59485055, compoundYield 65%

Procedure

By using 2-[(benzyloxy)methyl]-5-bromo-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran (690 mg, 1.84 mmol) synthesized in Reference Example 159 and 1-(4-methoxyphenyl)piperazine (707 mg, 3.68 mmol), the reaction was carried out in the same manner as Example 1 to synthesize 580 mg of the title compound (yield 65%). An oily product.

Sources & evidence

ORD record
ord-0ad93a17903f4478be7ea14bb884ae49
Source dataset
uspto-grants-2015_02
Patent number
US08957069B2

Reaction notes

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