Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-Aminopyridazine-3-carboxylic acid → 3-(6-Amino-pyridazine-3-carbonyl)-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-Aminopyridazine-3-carboxylic acid | HCID 12200479 | — |
| 반응물 | 8-Boc-3,8-diaza-bicyclo(3.2.1)octane | HCID 15740908 | — |
| 생성물 | 3-(6-Amino-pyridazine-3-carbonyl)-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester | HCID 67355347 | 51% |
반응 단계
Following general amide formation method 1, 6-amino-pyridazine-3-carboxylic acid (212 mg, 1.0 mmol) was combined with 3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (139 mg, 1.0 mmol), which gave 3-(6-Amino-pyridazine-3-carbonyl)-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester as a white solid (169 mg, 0.51 mmol) in 51% yield. MS m/z 334.4 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08957074B2 |
| 출처 데이터셋 | uspto-grants-2015_02 |
| ORD ID | ord-0bfa1c5693e04cbb8ce47b81abe26ffd |
| 출처 메모 | uspto-grants-2015_02 |