HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Boc-9-oxa-3,7-diazabicyclo[3.3.1]nonane → HCID 86686637, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Boc-9-oxa-3,7-diazabicyclo[3.3.1]nonane | HCID 18540412 | — |
| Reactant | 6-(7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)nicotinic acid | HCID 58315472 | — |
| Product | HCID 86686637 | HCID 86686637 | 34% |
Reaction Steps
Following general amide formation method 1, 6-(7-Cyclopentyl-6-dimethylcarbamoyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-nicotinic acid (266 mg, 0.438 mmol, 1.0 eq) was combined with 9-Oxa-3,7-diaza-bicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester (100 mg, 0.438 mmol, 1.0 eq) which gave 7-[6-(7-Cyclopentyl-6-dimethylcarbamoyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-pyridine-3-carbonyl]-9-oxa-3,7-diaza-bicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester as a light pink powder (90 mg) in 34% yield. MS m/z 605.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957074B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-fdcbdf986882426982a21cde10e38251 |
| Source note | uspto-grants-2015_02 |