HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2R)-2-(((tert-butoxy)carbonyl)amino)-3-methylbutanoic acid → HCID 67354797, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2R)-2-(((tert-butoxy)carbonyl)amino)-3-methylbutanoic acid | HCID 637605 | — |
| Reactant | 2-(5-(3,8-diazabicyclo[3.2.1]octane-3-carbonyl)pyridin-2-ylamino)-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide | HCID 53378674 | — |
| Product | HCID 67354797 | HCID 67354797 | 96.9% |
Reaction Steps
Following general amide formation method 1, 7-cyclopentyl-2-[5-(3,8-diaza-bicyclo[3.2.1]octane-3-carbonyl)-pyridin-2-ylamino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (60 mg, 0.123 mmol, 1.0 eq) was combined with BOC-D-Valine (26.7 mg, 0.123 mmol, 1.0 eq) which gave ((R)-1-{3-[6-(7-Cyclopentyl-6-dimethylcarbamoyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-pyridine-3-carbonyl]-3,8-diaza-bicyclo[3.2.1]octane-8-carbonyl}-2-methyl-propyl)-carbamic acid tert-butyl ester (82 mg) in 92% yield. HRMS m/z, (M+H)+: 688.3961.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957074B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-85c10dc5380f4c7d87fbf683f67c604f |
| Source note | uspto-grants-2015_02 |