5-Bromo-2-nitropyridine → HCID 67354756, compound

HRID 1850620Notes

Reaction equation

HRID 1850620 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([N+:8]([O-:10])=[O:9])=[N:6][CH:7]=1.[N:11]12[CH2:19][CH2:18][CH:15]([CH2:16][CH2:17]1)[NH:14][C:13](=[O:20])[CH2:12]2>>[N+:8]([C:5]1[N:6]=[CH:7][C:2]([N:14]2[CH:15]3[CH2:18][CH2:19][N:11]([CH2:17][CH2:16]3)[CH2:12][C:13]2=[O:20])=[CH:3][CH:4]=1)([O-:10])=[O:9]

Participants

3

Reactant 2

HCID 8176205-Bromo-2-nitropyridineHCID 44018501,4-Diazabicyclo(3.2.2)nonan-3-one

Product 1

HCID 67354756HCID 67354756, compoundYield 64%

Procedure

Following general N—C coupling procedure 1, 5-bromo-2-nitropyridine and 1,4-diazabicyclo[3.2.2]nonan-3-one were combined and gave 4-(6-nitropyridin-3-yl)-1,4-diazabicyclo[3.2.2]nonan-3-one (418 mg) in 64% yield.

Sources & evidence

ORD record
ord-d81152339de24f778e2d578cb6775e41
Source dataset
uspto-grants-2015_02
Patent number
US08957074B2

Reaction notes

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