HCID 67354835, compound → HCID 67355779, compound

Participants

Reaction Steps

Following general N—C coupling procedure 1, tert-butyl-3-(6-aminopyridin-3-yl)-4-oxo-3,9-diazabicyclo[4.2.1]nonane-9-carboxylate (119 mg, 0.359 mmol) was combined with 2-chloro-7-cyclobutyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (100 mg, 0.359 mmol) which gave tert-butyl 3-(6-(7-cyclobutyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl)-4-oxo-3,9-diazabicyclo[4.2.1]nonane-9-carboxylate (150 mg) in 73% yield. MS m/z 575.2 (M+H)+.

Provenance & Evidence