(R)-4-chloro-6-((1-methylpiperidin-3-yl)oxy)pyrimidin-5-amine → (R)-4((1-methylpiperidin-3-yl)oxy)pyrimidin-5-amine

Participants

Reaction Steps

(R)-4-chloro-6-((1-methylpiperidin-3-yl)oxy)pyrimidin-5-amine was dissolved in MeOH (15.0 mL) and Pd/C 10% (324.5 mg, 0.3049 mmol) was added and the reaction mixture stirred under a hydrogen atmosphere for 2 h. The reaction vessel was evacuated and flushed with nitrogen (3×), filtered through a celite pad washing with methanol followed by ethyl acetate. The combined filtrates were concentrated in vacuo to leave the title product 7a as a colourless oil (631 mg, 99%).

Provenance & Evidence