HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-((3-methyl-4-nitroisothiazol-5-yl)carbamoyl)benzoate → Methyl 2-((4-amino-3-methylisothiazol-5-yl)carbamoyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-((3-methyl-4-nitroisothiazol-5-yl)carbamoyl)benzoate | HCID 90411396 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 2-((4-amino-3-methylisothiazol-5-yl)carbamoyl)benzoate | HCID 90411342 | — |
Reaction Steps
Methyl 2-((3-methyl-4-nitroisothiazol-5-yl)carbamoyl)benzoate was suspended in MeOH (30 mL), Pd/C 10% (477.1 mg, 4.483 mmol) was added and the mixture was hydrogenated at RT under 1 atm of hydrogen (balloon pressure) for 2 h. The catalyst was filtered off and the mixture was concentrated in vacuo, yielding methyl 2-((4-amino-3-methylisothiazol-5-yl)carbamoyl)benzoate. (150 mg, 100%). MS (ES+) 292.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957078B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-7d8797577f3e4b8bb5a387b98543e0f7 |
| Source note | uspto-grants-2015_02 |