反应详情

温度

105 °C

A mixture of (6-chlorobenzotriazol-1-yl) 2-amino-6-fluoro-pyrazolo[1,5-a]pyrimidine-3-carboxylate (140.4 mg, 0.4038 mmol), 3-methyl-4-(pyrrolidin-1-yl)isothiazol-5-amine (37 mg, 0.2019 mmol) (synthesized according to preparation 13) in pyridine (3 mL) was heated at 105° C. for 24 h. The mixture was concentrated in vacuo and the residue was purified by fractionlynx. The clean fractions were combined and freeze dried to yield 2-amino-6-fluoro-N-(3-methyl-4-(pyrrolidin-1-yl)isothiazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide as a pale yellow solid. (25 mg, 26%). MS (ES+) 362.1.

1. concentrationThe mixture was concentrated in vacuo
2. customthe residue was purified by fractionlynx
3. customfreeze dried