Methylamine ethanol → HCID 66642638, compound

HRID 1850706Notes

Reaction equation

HRID 1850706 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[C:4](N(C)C=O)[CH:3]=1.[CH2:18]([OH:20])C.[CH3:21][NH2:22]>>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[C:4]([C:18]([NH:22][CH3:21])=[O:20])[CH:3]=1

Participants

3

Reactant 2

HCID 22028356Methylamine ethanolHCID 131732453HCID 131732453, compound

Product 1

HCID 66642638HCID 66642638, compound

Procedure

Embodiment 6: Preparation of 4-chloro-6-methoxyl-N-methyl-2-quinolinyl formamide 10 g of 4-chloro-6-methoxyquinolinyl-2-carbonyl chloride (obtained from embodiment 1) was reacted with 200 ml of 2M methylamine ethanol solution under 0° C. for 36 hours until the reaction finished. The solvent was evaporated under vacuum and the residues were added with water followed by stirring evenly. Ethyl acetate was added for extracting and the ethyl acetate layer was dried with anhydrous sodium sulfate. The ethyl acetate layer was removed under vacuum to obtain 9 g of 4-chloro-6-methoxy-N-methyl-2-quinoline carboxamide.

Workup

  1. customThe solvent was evaporated under vacuum
  2. additionthe residues were added with water
  3. additionEthyl acetate was added
  4. extractionfor extracting
  5. dry with materialthe ethyl acetate layer was dried with anhydrous sodium sulfate
  6. customThe ethyl acetate layer was removed under vacuum

Sources & evidence

ORD record
ord-3ef4a321b7aa449eb46bf972af1fa6a3
Source dataset
uspto-grants-2015_02
Patent number
US08957087B2

Reaction notes

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