HCID 70818668, compound → HCID 70818711, compound

Participants

Reaction Steps

To a solution of cyclopropyl{2,6-difluoro-4-[(4-methoxybenzyl)oxy]phenyl}methanol (860 mg, 2.73 mmol) in DCM (137 mL) cooled to 0° C. via ice water bath was added 4-methoxylmorpholine N-oxide (481 mg, 4.10 mmol) followed by TPAP (96 mg, 0.27 mmol) and the resulting mixture was stirred for 20 minutes. The mixture was directly loaded onto a silica gel column (80 g, ISCO, eluting with a gradient of 10-30% ethyl acetate hexane) and purified to afford the title compound (728 mg, 85%). LC/MS 319 (M+H)+.

Provenance & Evidence