benzyl 4-[(1R,2S)-2-(2-{4-[2-(dimethylamino)-2-oxoethyl]-2,5-difluorophenoxy}ethyl)cyclopropyl]piperidine-1-carboxylate → 2-(2,5-difluoro-4-{2-[(1S,2R)-2-piperidin-4 ylcyclopropyl]ethoxy}phenyl-)-N,N-dimethylacetamide

Participants

Reaction Steps

To a solution of benzyl 4-[(1R,2S)-2-(2-{4-[2-(dimethylamino)-2-oxoethyl]-2,5-difluorophenoxy}ethyl)cyclopropyl]piperidine-1-carboxylate (226 mg, 0.451 mmol) in 2 ml anhydrous methanol at RT was added 10% Palladium on carbon (25.0 mg, 0.211 mmol). The reaction was stirred with hydrogen balloon for 2 hours. It was filtered by Celite, and the filtrate was concentrated to give the title compound (160 mg, 97%). LC/MS (m/z): 368.4 (M+H)+.

Provenance & Evidence