反应详情

To a solution of 1.16 g (2.53 mmol) benzyl 4-[(1R,2S)-2-(2-{[5-(methylsulfonyl)pyridin-2-yl]oxy}ethyl)cyclopropyl]piperidine-1-carboxylate in 15 ml anhydrous methanol at ambient temperature was added 0.12 g (1.13 mmol) palladium on carbon, 10% by weight. The solution was stirred under hydrogen for 4 hours and filtered. The crude product was concentrated to give the title compound as white solid and used for the next step. LC/MS 325.5 (M+1).

1. filtrationfiltered
2. concentrationThe crude product was concentrated