反应详情

The ether, 2-[4-((1R,2S)-2-{2-{2-fluoro-4-(methylsulfonyl)phenoxy]ethyl}cyclopropyl)piperidine-1-yl]-1-phenylethanone (740 mg, 1.62 mmol) in ethanol (25 mL) was added Palladium on carbon (10 wt. %, wet, 0.200 g), degassed (3× vacuum/H2) again and stirred under H2 at 1 atm for 64 h. The reaction mixture was filtered through a plug of celite, and the filter cake rinsed with ethanol (150 mL), ethyl acetate (150 mL), and the filtrate was concentrated under reduced pressure to provide the piperidine as a yellow oil. MS (ESI): 342 [M+H]+.

1. customdegassed (3× vacuum/H2) again
2. filtrationThe reaction mixture was filtered through a plug of celite
3. washthe filter cake rinsed with ethanol (150 mL), ethyl acetate (150 mL)
4. concentrationthe filtrate was concentrated under reduced pressure