Benzyl 4-((1R,2S)-2-(2-hydroxyethyl)cyclopropyl)piperidine-1-carboxylate → 2-((1S,2R)-2-(piperidin-4-yl)cyclopropyl)ethanol

Participants

Reaction Steps

Benzyl 4-((1R,2S)-2-(2-hydroxyethyl)cyclopropyl)piperidine-1-carboxylate (10 g, 33 mmol) was dissolved in 100 mL of EtOAc/MeOH (1:1 v/v), to which was added 1 g of 5% Pd/C and apply hydrogen balloon. After stirring at rt for 1 h, the reaction mixture was filtered through Celite to give the product that was used in the next step without further purification. Rf was 0 @ 50% EtOAc in hexanes (blue spot on CAM stain).

Provenance & Evidence