HCID 70856305, compound → HCID 70856333, compound

Participants

Reaction Steps

Benzyl 4-[(1R,2S)-2-(2-{[5-(2-tert-butoxy-2-oxoethyl)-3-methylpyridin-2-yl]oxy}ethyl)cyclopropyl]piperidine-1-carboxylate (2.6 g, 5.1 mmol) in 30 mL of EtOH was treated with 10% palladium on carbon (300 mg) for 2.5 hrs under 1 atm. of hydrogen gas. The suspension was filtered through a celite pad and concentrated in vacuo to give product used for the next reaction without further purification. LCMS (ESI) m/z 375 [M+H]+.

Provenance & Evidence