HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1850805Generated: October 25, 2026
Trifluoroacetic acid → 5-(Cyclopropylamino)-7-(4-dimethylamino-3-methylphenyl)-[1,6]naphthyridine
https://huagongshe.com/reaction/1850805
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Reactant | 5-Chloro-7-(4-dimethylamino-3-methylphenyl)-[1,6]naphthyridine | HCID 44632882 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-(Cyclopropylamino)-7-(4-dimethylamino-3-methylphenyl)-[1,6]naphthyridine | HCID 58483112 | — |
Reaction Steps
100 mg (0.34 mmol) 6.1, 75 μL (1.07 mmol) cyclopropylamine were dissolved in 500 μl dimethylformamide and stirred overnight at 100° C. The mixture was combined with acetonitrile/water and trifluoroacetic acid and purified by chromatography (RP-HPLC). The corresponding fractions were freeze-dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08957088B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-8db4bd22b5be48b0a4e6e9c9a2995329 |
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| Source note | uspto-grants-2015_02 |
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