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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1850838Generated: October 25, 2026

1-(4-Fluorophenyl)cyclobutanecarboxylic acid → 1-[1-(4-Fluorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-ol

https://huagongshe.com/reaction/1850838

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(4-Fluorophenyl)cyclobutanecarboxylic acidHCID 16769017—
Reactant1-[1-(4-Chlorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-olHCID 58246243—
Product1-[1-(4-Fluorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-olHCID 58246350—

Reaction Steps

The compound was prepared analogously to 1-[1-(4-chlorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-ol (cf. example 82) starting from 1-(4-fluorophenyl)cyclobutanecarboxylic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08957089B2
Source datasetuspto-grants-2015_02
ORD IDord-2881ce32171d490bba677e1ed8b1992e
Source noteuspto-grants-2015_02