HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-({1-[1-(4-Fluorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine → 2-({1-[1-(4-Chlorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-6-yl}oxy)ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-({1-[1-(4-Fluorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine | HCID 58246324 | — |
| Reactant | 1-[1-(4-Chlorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-6-ol | HCID 136019354 | — |
| Product | 2-({1-[1-(4-Chlorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-6-yl}oxy)ethanamine | HCID 58246261 | — |
Reaction Steps
2-({1-[1-(4-Chlorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-6-yl}oxy)ethanamine was prepared analogously to 2-({1-[1-(4-fluorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine using 1-[1-(4-chlorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-6-ol in place of 1-[1-(4-fluorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-ol (cf. example 65).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08957089B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-9bc19c8143cc43808fda3fff898cde14 |
| Source note | uspto-grants-2015_02 |