Sodium borohydride → N'-[2-({1-[1-(4-Chlorophenyl)cyclobutyl]-4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl}oxy)ethyl]-N,N-diethylsulfuric diamide hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Sodium borohydride	HCID 4311764	—
Reactant	N'-[2-({1-[1-(4-Chlorophenyl)cyclobutyl]-4,4-dimethyl-3,4-dihydroisoquinolin-7-yl}oxy)ethyl]-N,N-diethylsulfuric diamide	HCID 66868671	—
Product	N'-[2-({1-[1-(4-Chlorophenyl)cyclobutyl]-4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl}oxy)ethyl]-N,N-diethylsulfuric diamide hydrochloride	HCID 66868967	—

Reaction Steps

N′-[2-({1-[1-(4-Chlorophenyl)cyclobutyl]-4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl}oxy)ethyl]-N,N-diethylsulfuric diamide hydrochloride was prepared analogously to example 65 using N′-[2-({1-[1-(4-chlorophenyl)cyclobutyl]-4,4-dimethyl-3,4-dihydroisoquinolin-7-yl}oxy)ethyl]-N,N-diethylsulfuric diamide (68 mg, 0.13 mmol) and sodiumborohydride (10 mg, 0.26 mmol). Yield: 60 mg (0.11 mmol, 82%, colorless foam).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08957089B2
Source dataset	uspto-grants-2015_02
ORD ID	ord-cadd3357d5104aef8f48b21efe62d27e
Source note	uspto-grants-2015_02