2-Bromo-1,1-dimethoxyethane → HCID 178461078, compound

Participants

Role	Name	HCID	Charge
Reactant	2-Bromo-1,1-dimethoxyethane	HCID 81672	—
Reactant	Sodium Methoxide	HCID 10942334	—
Reactant	benzyl (NE)-N-[[1-[1-(4-fluorophenyl)cyclobutyl]-7-[2-(propylsulfonylamino)ethoxy]-3,4-dihydro-1H-isoquinolin-2-yl]-(phenylmethoxycarbonylamino)methylidene]carbamate	HCID 88239773	—
Solvent	Ethanol	HCID 702	—
Product	HCID 178461078	HCID 178461078	—

Reaction Conditions

Temperature	120 °C

Reaction Steps

1-[1-(4-Fluorophenyl)cyclobutyl]-7-{2-[(propylsulfonyl)amino]ethoxy}-3,4-dihydroisoquinoline-2(1H)-carboximidamide acetate (140 mg, 0.255 mmol, cf. example 72) was suspended in ethanol (2 mL). Sodium methylate (138 mg, 0.142 mmol) and 2-bromo-1,1-dimethoxyethane (65 mg, 0.383 mmol) were added. The reaction mixture was stirred at 120° C. in the microwave (80 W) for 80 min. The solvent was evaporated in vacuo and the crude product was used without further purification for the next step.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08957089B2
Source dataset	uspto-grants-2015_02
ORD ID	ord-dac8a291d0854f5c9f171daba5b74ca5
Source note	uspto-grants-2015_02