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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1850863Generated: October 30, 2026

Morpholine → 1-[1-(4-Chlorophenyl)cyclobutyl]-7-[3-(morpholin-4-ylsulfonyl)propoxy]-1,2,3,4-tetrahydroisoquinoline hydrochloride

https://huagongshe.com/reaction/1850863

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
Reactant3-({1-[1-(4-Chlorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-yl}oxy)propane-1-sulfonyl chlorideHCID 58246196—
Product1-[1-(4-Chlorophenyl)cyclobutyl]-7-[3-(morpholin-4-ylsulfonyl)propoxy]-1,2,3,4-tetrahydroisoquinoline hydrochlorideHCID 44465552—

Reaction Steps

The compound was prepared analogously to example 82 from 3-({1-[1-(4-chlorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-yl}oxy)propane-1-sulfonyl chloride using morpholine in place of 1-propylamine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08957089B2
Source datasetuspto-grants-2015_02
ORD IDord-2438a91056824658ac88e9c75b83e3c3
Source noteuspto-grants-2015_02