Methanol → HCID 66868903, compound

Participants

Reaction Steps

A solution of 1-[1-(4-chlorophenyl)cyclopropyl]-7-methoxy-3,4-dihydroisoquinoline (700 mg, 2.2 mmol) in methylenehloride (10 ml) under nitrogen was cooled to −78° C. Borontribromide (BBr3, 4.2 ml 1M in methyleneloride, 4.2 mmol) was added dropwise. The reaction was allowed to warm up to room temperature and stirred overnight. Methanol was added (5 ml) and the resulting mixture poured into water neutralized with 1M sodiumbicarbonate and extracted consecutively with methylenehloride and water. The organic layer was dried (Na2SO4), the solvents removed and the black residue purified by chromatography. Yield: 320 mg, (1.1 mmol, 48%).

Provenance & Evidence