Sodium Hydroxide → HCID 10374990, compound

HRID 1851083Notes

Reaction equation

HRID 1851083 reaction equation
[OH-].[Na+].[O:3]=[C:4]1[C:9]([C:10]([O:12]CC)=[O:11])=[CH:8][NH:7][N:6]2[CH:15]=[CH:16][CH:17]=[C:5]12>C(O)C>[O:3]=[C:4]1[C:9]([C:10]([OH:12])=[O:11])=[CH:8][NH:7][N:6]2[CH:15]=[CH:16][CH:17]=[C:5]12

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10104421ETHYL 4-OXO-1,4-DIHYDROPYRROLO[1,2-B]PYRIDAZINE-3-CARBOXYLATE

Product 1

HCID 10374990HCID 10374990, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

2 M sodium hydroxide aqueous solution was added to a suspension of ethyl 4-oxo-1,4-dihydropyrrolo[1,2,b]pyridazin-3-carboxylate in ethanol (165 mL) and stirred overnight at 100° C. The resulting reaction mixture was cooled to room temperature, distilled under reduced pressure, and concentrated. Then, concentrated hydrochloric acid was added until pH decreased to 2. Thereafter, the solid was filtered, washed with water and dried in vacuum. The target compound obtained was subjected to the next step without further purification.

Workup

  1. customThe resulting reaction mixture
  2. temperaturewas cooled to room temperature
  3. distillationdistilled under reduced pressure
  4. concentrationconcentrated
  5. additionThen, concentrated hydrochloric acid was added until pH
  6. filtrationThereafter, the solid was filtered
  7. washwashed with water
  8. customdried in vacuum
  9. customThe target compound obtained
  10. customwas subjected to the next step without further purification

Sources & evidence

ORD record
ord-cfe3ec87e500410f9d2862fb23efa607
Source dataset
uspto-grants-2015_02
Patent number
US08957102B2

Reaction notes

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