N-bromobutanimide → HCID 58368367, compound

Participants

Reaction Steps

N-Bromosuccinimide (1.49 g, 8.42 mmol) was added to a solution of 4-(2-fluoro-4-nitrophenoxy)pyrrolo[1,2-b]pyridazine (2.30 g, 8.42 mmol) in anhydrous chloroform (70 mL) at 0° C. and stirred for 4 hours. Upon completion of the reaction, the resulting mixture was washed by adding water thereto. The organic layer was separated, dried with magnesium sulfate, and then filtered. The filtrate was concentrated by distillation under reduced pressure. The resulting residue was purified by silica gel chromatography (10% ethyl acetate in n-hexane) to give the target compound as a yellow solid (840 mg, 2.39 mmol, 28% yield).

Provenance & Evidence