Methyl 2-bromopropionate → HCID 86709164, compound

HRID 1851107Notes

Reaction equation

HRID 1851107 reaction equation
[CH2:1]([C:4]1[NH:5][C:6]2[C:11]([CH:12]=1)=[C:10]([C:13]([F:16])([F:15])[F:14])[C:9]([C:17]#[N:18])=[CH:8][CH:7]=2)[CH2:2][CH3:3].Br[CH:20]([CH3:25])[C:21]([O:23][CH3:24])=[O:22]>>[C:17]([C:9]1[C:10]([C:13]([F:15])([F:16])[F:14])=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]([CH:20]([CH3:25])[C:21]([O:23][CH3:24])=[O:22])[C:4]([CH2:1][CH2:2][CH3:3])=[CH:12]2)#[N:18]

Participants

3

Reactant 2

HCID 95576Methyl 2-bromopropionateHCID 674051552-propyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 86709164HCID 86709164, compound

Procedure

Synthesized in a manner similar to Example 1 using 2-propyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile and methyl 2-bromopropanoate: MS (ESI): m/z 339 (MH+).

Sources & evidence

ORD record
ord-46d73235625941ceb4ed072583020808
Source dataset
uspto-grants-2015_02
Patent number
US08957104B2

Reaction notes

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