Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1851110Generated: October 27, 2026

Methyl 2-bromopropionate → Methyl 2-(5-cyano-4-(trifluoromethyl)-1H-indol-1-yl)propanoate

https://huagongshe.com/reaction/1851110

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 2-bromopropionateHCID 95576—
Reactant4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67405449—
ProductMethyl 2-(5-cyano-4-(trifluoromethyl)-1H-indol-1-yl)propanoateHCID 57800469—

Reaction Steps

Synthesized in a manner similar to Example 1 using 4-(trifluoromethyl)-1H-indole-5-carbonitrile (see, for example, US2008139631A1) and methyl 2-bromopropanoate: MS (ESI): m/z 297 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08957104B2
Source datasetuspto-grants-2015_02
ORD IDord-bf18f709966741f0baf5f0086377a51e
Source noteuspto-grants-2015_02